|Location:||Ancient Ruins, Chapter 1|
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The Hand is a boss encounter near the end of Chapter 1.
It's a large robot which chases the player through a hallway, breaking things and firing bullets as it charges. It also has a vacuum arm attack where it sucks the player toward it.
Wait until the vacuum arm attack begins, then drop a bomb to be sucked up. Once it detonates hit the 'eye' of the robot while it's stunned.